Over the course of their storied career, the Temptations placed 38 hit records in the pop top 40—not just more than any other Motown Records artist, but more than any American pop group ever. Beyond their quantitative achievements, the Temptations also embodied the original Motown ideal that the records mattered more than the people who made them—for good and for ill. Indeed, in an era when pop groups were coming to be known as much for the personalities of their individual members as for their music, the Temptations—a group in which all five members sometimes sang lead—remained essentially unknowable other than through their incredible records. The Temptations were inducted into the Rock and Roll Hall of Fame in , but the deaths in quick succession of members David Ruffin, Eddie Kendricks and Melvin Franklin in , and , respectively, leaves Otis Williams as the sole surviving member of the original Temptations lineup. But if you see something that doesn’t look right, click here to contact us! On December 2, , a new federal agency opens its doors. Created in response to the dawning realization that human activity can have major effects on the planet, the Environmental Protection Agency heralded a new age of government action on behalf of the environment. The Corsican-born Napoleon, Militant abolitionist John Brown is executed on charges of treason, murder and insurrection on December 2,
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A Nature Research Journal. Such base editors have enormous potential in genome editing, gene therapy and precision breeding. Using cytidine deaminase base editors that elicit C-to-T mutations, we show here that high editing precision can be achieved by engineering the connection between the deaminase domain and the Cas domain of the editor. By systematically testing different linker sequences and removing non-essential sequences from the deaminase, we obtain high-precision base editors with narrow activity windows that can selectively edit a single cytidine at a specific position with high accuracy and efficiency.
These base editors will enable the use of genome editing in applications where single-nucleotide changes are required and off-target editing of adjacent nucleotides is not tolerable.
It is one of the least understood monogenic autoinflammatory diseases, both from a pathogenic and treatment perspective. Patients often have persistent symptoms refractory to biologic therapies that necessitate prolonged exposure to high dose corticosteroids. We studied 4 patients; 3 adults ages 52, 26, 18 and one pediatric age 16 patient. Two adults have the AT mutation and one has the EQ mutation. The fourth has a novel EK mutation. Clinically, all 4 patients have pyoderma gangrenosum PG lesions and 3 of the 4 have arthritis.
US cassette single EP (PRCS )) Promo: “Somebody To Love (Live at the “Killer/Papa Was A Rolling Stone (Live) (PM Dawn Remix)” George Michael -Date UnknownSteve Hackett releases his album Guitar Noir in the UK on.
Or are you looking for a simple reminder of your love to share with him on for no reason at all? No matter the occasion, dad and daughter quotes can help make your note to your dad extra special. Check out the quotes below for cute, funny, and inspirational messages for a father or daughter. The following quotes are as funny as they are filled with love for the special bond between fathers and daughters. Use these for a card or on a custom mug as a gift. These Daddy daughter quotes are cute for any age and for any occasion.
Fancy dining and casual restaurants alike are offering special menus and deals. Brad Plothow, vice president of corporate marketing and communications for Womply, a small-business software provider, said the holiday is a fairly typical day for local restaurants. Spend better, save better: All the money tips and advice delivered right to your inbox.
Most hereditary diseases in humans involve single-point mutations, the PAPAPAP largely restricting editing to positions −15 and −16 (Fig.
The Gosling family proudly introduces Papa Seal, the “father of all rums. Bermuda’s humid, salty sea air provides a superior aging environment. The rum is a blend of column and pot still rums distilled from molasses. This single barrel rum is aged for 15 years in once used bourbon barrels with a medium char. This Papa Seal release comes from 12 selected barrels which yielded bottles. Each bottle will display both the barrel and bottle number as well as the bottling date.
Due to the nature of single barrel releases, slight variances in flavor are to be expected. Nose: Molasses, vanilla bean and caramel all shine through on the nose, along with brown butter pound cake and caramelized bananas. Palate: The palate offers dark brown sugar with cinnamon and cloves, along with milk chocolate and more vanilla. Gosling Brothers Limited is a Bermuda company primarily concerned with blending and distributing rum as well as importing and distributing spirits on the island and maintaining a retail presence.
Photo by Martin and Renee Norred at Rabscuttle. Weighing my options, I scrapped my usual Friday night routine of after work yoga followed by beer drinking with my married neighbors. So there I was, perched at a table built long and low for third grade birthday parties, as I gripped my plastic mug of beer and observed the chaos and family dynamics.
I hope I can return the favor when I grow up by achieving every single goal that you always wanted me to. I love you.” – Unknown; “Nothing.
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How would the experience of online dating differ between Tinder, Bumble, and Hinge? Instead of swiping, you like and comment on individual photos or forum about the good works Papa Ork. Am from the United States.
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We asked some of our favorite dads of daughters to share their most-cherished dad and daughter activities, and we received a treasure trove of ideas. Read on to discover our 33 favorite things for father and daughter to do together. Go on a bike ride. Dads never forget the day when our daughters graduate from using training wheels to being able to ride solo on two wheels.
La Papa Loca is your destination for fries, featuring fries covered in marinated carne asada, chili cheese fries, garlic fries and more.
Ex hibit 3. General Corporation Law of. Designation and Amount. Such number of shares may be increased or decreased by resolution of the Board of Directors, provided , however that no such decrease shall reduce the number of shares of the Series A Preferred Stock to a number less than the number of shares then outstanding, plus the number reserved for issuance upon the exercise of options, rights or warrants, or upon conversion of any outstanding securities issued by the Company convertible into Series A Preferred Stock.
Dividends and Distributions. Accrued but unpaid dividends shall not bear interest. Dividends paid on Shares of Series A Preferred Stock in an amount less than the aggregate amount of all such dividends at the time accrued and payable on such Shares shall be allocated pro rata on a share-by-share basis among all Shares of Series A Preferred Stock at the time outstanding.
The Board of Directors may fix a record date for the determination of holders of Shares of Series A Preferred Stock entitled to receive payment of a dividend or distribution declared thereon, which record date shall be no more than 60 days prior to the date fixed for the payment thereof. Voting Rights. Any Director who shall have been so elected pursuant to this paragraph may be removed only for cause. Each such additional Director shall not be a member of any class of the Board of Directors, but shall serve until the next annual meeting of stockholders for the election of directors, or until his.
The absence of a quorum of the holders of Common Stock shall not affect the exercise by the holders of Shares of Series A Preferred Stock of such rights. Certain Restrictions.
Welcome to Friday Funnies where everything is all Coronavirus all the time. How can it be Friday Funnies, you say? When everything is serious all the time, how can one be expected to laugh? And seriously. How can anyone tell if you are laughing behind that face mask you have to wear all the time?
Padma Lakshmi is dating Adam Dell and in another searing blow, allegedly Lakshmi was teaching her little girl to call her boyfriend “Papa.”.
Madonna also has the largest amount of Number two singles too, with 12 over the years. Madonna has also been in films, including a breakout role in Desperately Seeking Susan as well as Evita and Swept Away. Madonna currently holds 16 Guinness World Records, from the slightly mad Most Costume Changes in A Film to the breathtaking Longest run of Top 20 hits by a solo artist 64 and Best-selling female recording artist of all time.
SIRE W Buy Listen. JIVE SIRE RHINO Facebook Twitter 5 Flipboard Reddit Email. New Top 40 charts announced in